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The positive outcomes from the part II examine led to a part III randomized, double-blind, placebo-controlled trial of sorafenib in patients with superior clear cell RCC.225 From November 2003 to March 2005, 903 patients with RCC that was proof against cytokine remedy have been randomly assigned to receive both continuous treatment with oral sorafenib (at a dose of four hundred mg twice each day) or placebo.
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